This article was forwarded to me.
-Brandon
---------- Forwarded message ----------
From: Ben Winnick <>
Date: Mon, Jul 5, 2010 at 10:47 AM
Subject: The Human Edge: Finding Our Inner Fish
To: Brandon Meredith <>
I found the following story on the NPR iPhone App:
http://www.npr.org/templates/story/story.php?storyId=127937070&sc=17&f=1001
The Human Edge: Finding Our Inner Fish
by Joe Palca
- July 5, 2010
It took him years of searching in the Canadian Arctic, but in 2004,
Neil Shubin found the fossilized remains of what he thinks is one of
our most important ancestors.
Turns out, it's a fish.
Shubin says his find, which he named Tiktaalik, represents an
important evolutionary step, because it has the structures that will
ultimately become parts of our human bodies. Shoulders, elbows, legs,
a neck, a wrist -- they're all there in Tiktaalik.
"Everything that we have are versions of things that are seen in
fish," says Shubin.
Of course, there are things that we have that Tiktaalik doesn't.
"We have a big brain, and portions of that big brain are not seen in
Tiktaalik," says Shubin. "But the template, all the way down to the
DNA that builds it, is already present in creatures like this."
Inside this fish, Shubin sees us.
"It's like peeling an onion," he says. "Layer after layer after layer
is revealed to you. Like in a human body, the first layer is our
primate history, the second layer is our mammal history, and on and on
and on and on, until you get to the fundamental molecular and cellular
machinery that makes our bodies and keeps are cells alive, and so
forth."
Our Inner Yeast
In fact, not only are we related to an ancient fish, but many of the
parts critical for making yeast are also critical for making us, says
Gavin Sherlock, a geneticist at Stanford University.
"About one-third of the yeast genes have a direct equivalent version
that still exists in humans," he says.
Sherlock says that not only do many of the same genes still exist in
humans and yeast, but they're so similar that you can exchange one for
the other.
"There are several hundred examples where you can knock out the yeast
gene, put in the human equivalent, and it restores it back to normal,"
he says.
Think about it, he says: We have a lot in common with yeast. Yeast
consume sugars like we do, yeast make hormones like we do, and yeast
have sex -- not quite like we do, but sex.
Sex isn't just fun and games. Sexual reproduction is critical for
stirring the genetic pot, speeding the evolution of endless forms most
beautiful, from fruit flies to blue whales to humans.
Now yeast is a single-celled organism. We have trillions and trillions
of cells in our bodies -- different kinds of cells, all fitting
together. How did that happen?
The answer is at the Field Museum in Chicago.
How We Got A Body
Shubin points to a display case in an exhibition on evolution. "This
tiny little diorama here, which you would just walk by, is arguably
one of the most important ones for understanding our bodies," he says.
"What you see is plastic fronds and jellyfish-like creatures in this
primitive ocean, but it's here where single-celled creatures like
bacteria and other microbes got together to make the first bodies."
And as time goes on, more forms emerge. Again, Shubin points at a
display that's easy to miss. Inside is an ancient worm: It has a left
and a right, a front and a back, a top and a bottom. These are the
same coordinate axes as our bodies.
"In fact, we believe, if you look at the evolutionary history of these
things, many of the genetic processes that make bodies like this and
bodies like our own arose over 500 million years ago," says Shubin.
As Shubin and I walk through the exhibit, we see the results of
tinkering with these genetic processes. Evolution brought fish,
dinosaurs, mammals. Finally, we come to a familiar-looking 4-foot tall
creature.
What Makes Humans Different
This is Lucy, an Australopithecus. She's more apelike than modern
humans, but getting there. Despite Lucy's proximity to humans, she's
clearly not human. Australopithicus went extinct.
On the way to us, something changed, and it was something more than
just physical.
Shubin points to a cabinet across the room. Inside is a re-creation of
a prehistoric human burial site. There's the skeleton of a woman who
has been placed in the grave, surrounded by her jewelry.
"It's hard to look at this as a fossil anymore," says Shubin. "You
look at this as a person who lived, and people loved this person
enough to do this. And that's what changed."
Shubin says it's not a bone or a muscle or a gene that made us human.
It was something else.
"The physiology and genetics made this possible. That's the template
that made all this happen," he says. "But when was that spark, when
was that moment? We don't know."
That moment that gave us the evolutionary edge that led to what we are
today -- the species that buries its dead, builds museums, explores
outer space. Shubin says it's the culture we built with our bones and
muscles and brains that makes our species unique. [Copyright 2010
National Public Radio]
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